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Cutting steroids uk
Cortisol also increases the synthesis of gluconeogenic enzymes, in particular phosphoenolpyruvate carboxykinase (PEPCK, encoded by the PCK1 gene) and glucose-6-phosphatase (G6P, encoded by the G6PC gene). The increased rate of protein metabolism leads to increased urinary nitrogen excretion and the induction of urea cycle enzymes. In order to effectively accomplish these metabolic changes glucocorticoids inhibit several energy-consuming processes such as digestion, and reproduction, as well as inflammatory and other immune responses. The anti-inflammatory activity of the glucocorticoids is exerted, in part, through inhibition of phospholipase A 2 (PLA 2 ) activity with a consequent reduction in the release of arachidonic acid from membrane phospholipids, cutting steroids uk. Arachidonic acid serves as the precursor for the synthesis of various eicosanoids.
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