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This cardiotoxicity was not observed in trials of the other aromatase inhibitor drugs. Of cardiotoxicity reported in clinical trials [32]. Letrozole, mbc metastaticbreastcancer, os overallsurvival, pcr pathologicalcomplete response, pfs. Letrozole is an oral non-steroidal aromatase inhibitor approved for the treatment of hormonally responsive breast cancer after surgery. It has been used (off-label) for ovulation induction as part of the ivf process since 2001. Femara (chemical name: letrozole) some targeted therapies: herceptin (chemical name: trastuzumab) herceptin hylecta (chemical name: trastuzumab and hyaluronidase-oysk) herzuma (chemical name: trastuzumab-pkrb) ontruzant (chemical name: trastuzumab-dttb) tykerb (chemical name: lapatinib) some pain medications also can cause sleeping problems. Data on tamoxifen and ais (ie, letrozole, anastrozole, and exemestane) were extracted from pharmacy records including the dispensing dates and number of days the drugs were supplied. They also corroborate the signal for severe heart failure observed in the breast international group (big) 1-98 trial (letrozole: 0. To date, however, few rcts have assessed the cardiovascular safety of ais in the sequential setting with tamoxifen. In this article we review the available literature on cardiotoxicity of aromatase inhibitors and provide some practical advice to improve the cardiovascular safety profile of these drugs. Previous article in issue. Commonly reported side effects of letrozole include: bone fracture, arthralgia, edema, dizziness, fatigue, hypercholesterolemia, osteoporosis, and flushing. Other side effects include: myalgia. See below for a comprehensive list of adverse effects. Applies to letrozole: oral tablet
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